Leuven Living Tissue Bank (LLTB)

For all tumor samples, we attempt to grow the tumor cells in vitro to generate patient-derived cell lines (PDCLs), which will be fully characterised using state-of-the-art genetic and pathological profiling. All PDCLs are stored in a repository called the ‘Leuven Living Tissue Bank’ (LTB), which will become available to researchers and contain matching patient and experimental data.

We have put major efforts in developing a large panel of patient-derived models derived from brain tumors. This was achieved by attempting to grow tumor samples in multiple cell culture conditions. As such, we achieve high take rates to develop new cell lines. This allowed us to grow cultures from different locations within the same tumor: we have cultures available from the “core” and “periphery” from the same tumor derived from >20 GBM patients.

Not only within the same tumor, but also across time we try to collect tumor samples from the same patient. We managed to develop “paired” tumor samples derived from a first and consecutive surgery of the same patient. This gives us the unique opportunity to study resistance mechanisms in GBM and how to circumvent them.

Overall, we have been able to bank a large amount of brain tumor samples derived from multiple sites across Belgium. All these samples have been cryopreserved and are available in collaboration. Please reach out to Prof. Frederik De Smet for more information.

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Leuven Living Tissue Bank (LLTB)

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